摘要
介绍了人工合成高分子材料聚乳酸 (PLA)的性质 ,综述了PLA和乳酸 /羟基乙酸共聚物 (PLGA)微球的生物降解性和生物相容性。其生物降解为均匀降解 ,材料相对分子质量及其分布对降解行为有很大影响。注射微球的组织反应分为 3个阶段 ,做组织相容性考察时应注意药物或生物活性物质的细胞毒性、抗原性和愈合作用对组织反应的影响。
The biodegradation of PLA(poly-lactic acid) and PLGA(poly-lactyl coglycolid) mincrospheres is a homogeneous process and be influenced by relative molecular weight and its distribution,and size of the microspheres.The tissue response to biodegradable microspheres injected may be characterized by three phases.The biodegradation and biocompatibility of PLA and PLGA microspheres were reviewed by the author.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第1期67-71,共5页
Chinese Journal of New Drugs
