摘要
目的 探讨尿毒症糖代谢紊乱的有关因素 ,分析尿毒症糖代谢紊乱与心血管病变的关系。方法 回顾性分析 2 19例尿毒症患者的临床资料 ,分析空腹血糖水平与肾功能衰竭 (肾衰 )程度、动脉血压及高血压、心脏扩大和眼底动脉硬化等尿毒症心血管病变的关系。结果 (1)14 .2 %的尿毒症患者空腹血糖水平≥ 7.8mmol/L ,呈现 2型糖尿病样糖代谢紊乱 ,肾衰严重组空腹血糖水平显著高于肾衰较轻组 ;(2 )高血糖组较正常血糖组血肌酐水平显著升高 ,贫血更为严重 ;(3 )高血糖组较正常血糖组动脉血压显著升高 ,高血压、心脏扩大和眼底动脉硬化单独或合并存在的发生率显著增加 ;合并上述一个或多个心血管病变组空腹血糖水平显著高于无上述病变组。结论 尿毒症糖代谢紊乱的发生与严重肾衰本身有关 。
Objective To analyze the factors inducing impaired glucose metabolism in uremia,and to analyze the associations between the impaired glucose metabolism and the cardiovascular disease in uremia.Methods The clinical data of 219 uremic patients were analyzed restrospectively,and the associations between the fasting blood glucose(FBG) level and the degree of renal failure,blood pressure and the incidences of hypertension,heart enlargement and atherosclerosis of retina were analyzed.Results (1)The FBG level as high as 7.8 mmol/L(140 mg/dL) or more was seen in 31 uremic patients(14.2%),and the group with severe renal failure(Scr<707.2 umol/L or Hb≤60 g/L) had significant higher FBG level than that without(Scr≥707.2 umol/L or Hb>60 g/L);(2)The hyperglycemic patients had significant higher serum creatinine(Scr) values and lower hemoglobin(Hb)levels than the euglycemic ones;(3)The hyperglycemic patients had significant higher blood pressure and higher incidences of hypertension,heart enlargement and atherosclerosis of retina than the euglycemic ones,and the patients with one or more cardiovascular diseases above had significant higher FBG levels than those without.Conclusion The impaired glucose metabolism in uremia may be due to severe renal failure,and it may be associated with the development of the cardiovascular disease in uremia.
出处
《临床内科杂志》
CAS
北大核心
2002年第2期123-125,共3页
Journal of Clinical Internal Medicine
