摘要
目的 观察C6胶质瘤大鼠瘤内给予顺铂缓释剂 ,ip顺铂后 ,顺铂在瘤内、脑组织、血及肾中的分布。方法 瘤内给予 1mg·m- 2 顺铂缓释剂 ,ip 5 0mg·m- 2顺铂后 ,然后在不同时间取样 ,用原子吸收分光光度法测量顺铂含量。结果 瘤内顺铂浓度瘤内用药比全身用药平均高 2～ 5 0倍 ,血及肾中的顺铂浓度瘤内用药仅为全身用药的 1.6 %～ 10 %和 0 .4 5 %～ 14 %。结论 瘤内用顺铂缓释剂可明显提高局部药物浓度 ,降低血 ,肾中顺铂分布 ,减轻全身毒副作用 。
AIM To assess the pharmacokinetic of intracranially administered cisplatin delivered from sustained releasing polymers for treatment of experimental gliomas in rats. METHODS C6 glioma cells were injected intracranially into rats, and the polymer loaded with cisplatin (1 mg·m -2 ) was implanted at the site of tumor on d 7 after C6 glioma cells were injected, meanwhile cisplatin solution (50 mg·m -2 ) was injected ip in the systemic administration group. At different times, the rats were sacrificed to collect tumor, brain tissue, blood and kidney samples to measure the platinum concentration by flameless atomic absorption spectroscopy (FASS). RESULTS The platinum level at tumor center in rats receiving intratumoral injection of cisplatin loaded polymer was compared with that in rats receiving intraperitoneal administration of high doses of cisplatin solution. The platinum level at tumor center following local injection was 2 to 50 times higher than that following systemic injection. Platinum concentration in blood and kidney after intratumoral administration was only 1.6%-10% and 0.45%-14% of that after systemic administration repectively. Biodegradable sustained releasing polymers can safely deliver cisplatin intracranially. CONCLUSION Intracranially administered biodegradable sustained releasing cisplatin polymer could safely deliver higher concentration of platinum at tumor center than systemic administration of cisplatin solution.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2002年第1期66-69,共4页
Chinese Journal of Pharmacology and Toxicology
