摘要
目前实体瘤疗效评价标准存在诸多不足,为了对抗肿瘤药的早期药效进行更精准的评价,给肺癌A549模型鼠以灌胃方式灌注顺铂进行治疗,并于给药前后分别进行18 F-FLT MicroPET显像,根据瘤组织的放射性摄取值变化评价顺铂对肺癌A549模型鼠的早期疗效,同时采用传统抗肿瘤药药效评价方法作对比,结合病理切片进一步验证实验结果。结果显示,给药第2天,MicroPET显像可见治疗组肿瘤的放射性摄取由(4.91±0.71)%ID.g-1降至(3.87±0.61)%ID.g-1,降幅达21.28%;而治疗组和空白组的肿瘤体积在给药后9d才出现显著性差异(P<0.01)。以上结果表明,18 F-FLT MicroPET显像较传统的肿瘤体积测量能更早、更精准地评价顺铂的抗肿瘤药效。
In order to investigate the feasibility of 18F-FLT MicroPET in the early efficacy of the antineoplastic drug. Twelve A549 lung carcinoma-loaded mice were randomly divided into 2 groups（control and treatment group, n=6 in each group）. Cisplatin （DDP, 25 mg/ kg） and saline were injected intragastricaly everyday to the treatment and control group, respectively. Tumor volume and weight were detected everyday and 18 F-FLT MicroPET scans were performed at 0, 2, 5, 9, 14 d. The MicroPET results showed that after the second ad-ministration, the tumor uptake of treatment group decreased 21. 28%, from （4. 91±0. 71）%ID/g to （3.87±0.61）%ID/g, while tumor volume was significantly decreased until 9 d （P〈0.01）. Compared with traditional method, MicroPET can detect much earlier and more accurate efficacy of antitumor agents.
出处
《同位素》
CAS
2011年第B12期80-84,共5页
Journal of Isotopes
基金
国家自然科学基金资助项目(81101077
81171399)
卫生部核医学重点实验室开放课题(KF200982
KF201112)
