摘要
目的 :探讨 2型糖尿病患者脂代谢紊乱与并发冠心病 (CHD)的关系。方法 :对 5 6例 2型糖尿病 (DM)患者 (其中 32例并发冠心病 ) ,测定其血脂、载脂蛋白浓度及血糖、胰岛素水平 ,与 30例例健康人进行比较。结果 :与对照组比较 ,2型 DM并发 CHD患者高密度脂蛋白胆固醇 (HDL- C)水平降低 (P<0 .0 0 5 ) ,低密度脂蛋白胆固醇(L DL - C)及载脂蛋白 B(Apo B)水平升高 (P<0 .0 5 )。单纯 2型 DM组仅有 HDL - C水平的降低 (P<0 .0 0 5 )及 L DL -C水平的升高 (P<0 .0 5 ) ,无 Apo B的变化 ;单纯 DM及 DM+CHD组血糖及胰岛素水平无显著差别 ,但均较对照组升高非常显著 (P<0 .0 0 5 ) ;DM+CHD组的 Apo B水平较单纯 DM组的显著升高 (P<0 .0 5 )。结论 :本组结果提示 HDL - C水平的降低、 L DL - C及 Apo B水平的升高是 2型 DM并发冠心病的重要危险因素。
Objective:To investigate the relationship between lipid metabolic disorder and coronary heart disease (CHD) in patients with type 2 diabetes mellitus (DM).Methods:We measured blood lipids?apolipoprotein? fasting glucose and fasting insulin in 56 patients with type 2 DM with or without CHD,compared to 30 normal persons.Results:The group of type 2 DM had significantly lower level of HDL-C, higher level of LDL-C and ApoB than normal persons( P <0.005,<0.05,<0.05 in oder).The group of type 2 DM with CHD had higher level ApoB than that without CHD ( P <0.05),compared control group,glucose and insulin levels were significantly increased( P <0.005) in 2 DM with and without CHD group,but there were no significant difference between 2 DM with and without CHD group.Conclusion:ApoB is also an important risk factor for development of CHD in patients with type 2 DM.
出处
《心血管康复医学杂志》
CAS
2002年第1期23-25,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
2型糖尿病
冠心病
血脂代谢
载脂蛋白
CHD
DM
Type 2 diabetes mellitus
Coronary heart disease
Lipids metabolism
Apolipoprotein
