摘要
目的评价联合测定糖尿病患者的血清果糖胺(FMN)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平变化在糖尿病微血管病变诊断中的意义。方法选择2013年4月至2014年4月就诊的2型糖尿病患者138例,根据2型糖尿病诊断标准,分为糖尿病无微血管病变组53例,糖尿病微血管病变组85例;选择同期体检健康的健康者65例作为健康对照组。采用胶乳增强免疫比浊法检测HbA1c,采用果糖胺氮蓝四唑法检测FMN,采用葡萄糖氧化酶法检测FPG,采用CHOD-POD法检测TC,采用直接法-表面活性剂清除法检测LDL-C。结果糖尿病组与健康对照组比较、糖尿病无微血管病变组和糖尿病微血管病变组分别与健康对照组比较、糖尿病微血管病变组与糖尿病无微血管病变组比较,血清FMN、HbA1c和FPG水平均明显升高;糖尿病组与健康对照组比较,LDL-C和TCH水平均明显升高,差异均有统计学意义(P<0.05)。相关性分析结果表明,FPG水平与HbA1c水平呈正相关(r=0.435 2,P<0.05),与FMN水平呈正相关(r=0.418 9,P<0.05);HbA1c水平与FMN水平呈正相关(r=0.457 3,P<0.01)。结论血清FMN、HbA1c和FPG水平是诊断糖尿病微血管病变的重要指标,三者联合测定在糖尿病微血管病变诊断中具有重要意义。
Objective To evaluate the significance of the joint determination of serum fructosamine （FMN） , glycated hemoglobin（HbA1c） ,fasting plasma glucose（FPG） ,total cholesterol（TC） and low density lipoprotein cho‐lesterol（LDL‐C） levels in the diagnosis of diabetic microangiopathy .Methods 138 patients with type 2 diabetes mel‐litus（T2DM ） in our hospital from April 2013 and April 2014 were selected and divided into the diabetic microangiop‐athy group（85 cases） and the non‐diabetic microangiopathy group（53 cases） according to the diagnostic criteria of T2DM ;contemporaneous 65 individuals of healthy physical examination were selected as the healthy control group . The latex enhanced immune turbidimetric method was adopted to detect HbA 1c ,FMN was detected by the fruc‐tosamine nitroblue tetrazolium method ,FPG was detected by the glucose oxidase method ,TC was detected by the CHOD‐POD method and LDL‐C was detected by the direct method‐surfactant cleaningmethod .Results Compared with the healthy control group ,serum FMN ,HbA1c and FPG levels in the DM group ,diabetic microangiopathy group and non‐diabetic microangiopathy group were significantly increased ,which in the diabetic microangiopathy group were significantly increased compared with non‐diabetic microangiopathy group ;compared with the healthy control group ,serum LDL‐C and TCH levels in the DM group were significantly increased ,the difference had statistical sig‐nificance（P〈0 .05） .The correlation analysis results showed that the FPG level was positively correlated with theH‐bA1c level（r=0 .435 2 ,P〈0 .05） and the FMN level（r=0 .418 9 ,P〈0 .05）;the HbA1c level was positively correla‐ted with the FMN level（r=0 .457 3 ,P〈0 .01） .Conclusion Serum FMN ,HbA1c and FPG levels are the important indicators for diagnosing diabetic microangiopathy ,their joint determination has great significance in the diagnosis of diabetic microangiopathy .
出处
《检验医学与临床》
CAS
2015年第1期61-62,65,共3页
Laboratory Medicine and Clinic
关键词
糖尿病
微血管病变
果糖胺
糖化血红蛋白
diabetes mellitus
microangiopathy
fructosamine
glycated hemoglobin
