摘要
目的 探讨胎盘防止母体 胎儿恶性肿瘤转移的屏障作用。方法 利用透射电镜研究 2例急性淋巴细胞白血病患者胎盘转移的超微结构。结果 在胎盘绒毛表面纤维蛋白沉积物中可见肿瘤细胞、溶解的细胞及细胞碎片。纤维蛋白沉积处及其附近常见合胞体脱落 ,并可见肿瘤细胞粘附于绒毛滋养层基底膜上。合胞体内有些肿瘤细胞基本保持完整的形态 ,有些则出现变性或坏死现象。结论 胎盘能杀伤和分解转移的肿瘤细胞 ,进而防止母体 -胎儿恶性肿瘤转移。
Objective To explain the barrier function of placenta against maternofetal tumor metastasis. Method The ultrastructure of placental metastatic tissue observed from 2 cases of maternal acute lymphatic leukemia was studied with electromicroscopy. Result On the surface of placenta villi,fibrinoid deposits,syncytial layer was often detached from trophoblastic basement membrane. Occasionally,tumor cells adherenting to the basement membrane were encountered. Some tumor cells in syncytium showed an intact morphology,whereas the others were degenerated or necrotic. Conclusion Placental syncytium can damage and lyse the metastatic tumor cells and thereby prevent the maternofetal tumor metastasis.
出处
《解剖学研究》
CAS
2001年第4期290-291,共2页
Anatomy Research
