摘要
目的 观察和比较头高位 (HUT)与站立位 (STD)对模拟失重所致股动脉收缩反应性降低的影响及其时间依赖性 .方法 49只雄性 SD大鼠随机分为对照组、模拟失重组、头高位 2 h组、头高位 4 h组、站立位 1 h组、站立位 2 h组和站立位 4h组 ,每组 7只 .利用离体股动脉血管环技术测定 7组大鼠股动脉对血管收缩剂的反应 .结果 悬吊大鼠股动脉血管环对 KCl和苯肾上腺素的收缩反应性显著降低 ;头高位与站立位组大鼠的股动脉血管环对 KCl和苯肾上腺素收缩反应均较悬吊组显著增强 ,与同步对照组相比已无显著差异 .结论 4wk模拟失重可以使大鼠股动脉的收缩反应性降低 ,而头高位与站立位均可对抗大鼠股动脉的收缩反应性的降低 .
AIM To examine and compare influence and time dependence of head up tilt (HUT) or standing (STD) on decline of contraction responses of rat femoral artery caused by simulated weightlessness. METHODS Forty nine male Sprague Dawley rats were divided into 7 groups: controlgroup, simulated weightless group, 2 h HUT group, 4 h HUT group, 1 h STD group, 2 h STD group and 4 h STD group. Responses to KCl and phenylephrine (PE) were examined in vitro using isolated femoral arterial rings. RESULTS The contractile responsiveness to KCl and PE of femoral arterial rings isolated from simulated weightless rats significantly decreased, as compared with control group. And the contractile responsiveness to KCl or PE of femoral arterial rings isolated from HUT and STD group significantly enhanced, as compared with that of simulated weightless rats. Whereas there was no difference among HUT, STD and control group. CONCLUSION Simulated weightlessness may result in an decreased contractile responses to KCl and PE of rat femoral artery. Both HUT and STD prevent the decrease of contractile response to KCl and PE of femoral arteries. The results indicate that intermittent artificial gravity is effective in counteract decreased contractile response of arteries induced by simulated weightlessness.
出处
《第四军医大学学报》
北大核心
2002年第1期68-71,共4页
Journal of the Fourth Military Medical University
基金
全军医药卫生科研基金资助项目 (98Z0 83 )
关键词
模拟失重
间断性人工重力
血管反应性
大鼠
simulated microgravity
intermittent artificial gravity
vascular responsiveness
rats
