摘要
目的 探讨血清胆红素与冠心病 (CHD)发病的关系。方法 将 190 5例患者按冠状动脉造影结果分为CHD组 ( 10 74例 )和对照组 ( 831例 )。采清晨空腹静脉血测定血清总胆红素浓度 ,比较两组间临床特征及实验室指标的差异 ,对血清总胆红素浓度与CHD之间的关系进行单因素及多元逐步Logistic回归分析。 结果 CHD组血清总胆红素浓度显著低于对照组 [( 12 .6± 6 .1)μmol/L和 ( 15 .9± 5 .7) μmol/L ,P <0 .0 1] ,单因素分析显示血清总胆红素浓度越低 ,CHD发病率越高 (P <0 .0 1)。多元逐步Logistic回归分析发现 ,血清总胆红素浓度与CHD的发生显著负相关(P =0 .0 0 0 1,OR =0 .939) ,低血清总胆红素浓度是CHD的独立危险因子。结论 血清总胆红素浓度减低可能在CHD的发病中具有一定的作用。
Objective To assess the relationship between serum bilirubin and coronary heart disease(CHD).Methods 1 905 cases with coronary angiography were divided into CHD group (1 074 cases) and control group (831 cases) according to the angiographic results. The clinical features and laboratory findings were reviewed. Univariate comparison and multiple logistic regression were applied to analyze the relationship between the total serum bilirubin concentration and CHD.Results The total serum bilirubin concentration was significant lower in the CHD group than that in the control group[(12.6±6.1) μmol/L vs (15.9±5.7 μmol/L,P<0.01)].Univariate analysis showed an inverse relationship between the serum bilirubin and the morbidity of CHD (P<0.01). The multivariate logistic regression indicated that low total serum bilirubin concentration is an independent risk factor of CHD (P=0.000 1.OR=0.939). Conclusion Low total serum bilirubin may play a role in the development of CHD.
出处
《临床内科杂志》
CAS
北大核心
2002年第1期14-15,共2页
Journal of Clinical Internal Medicine
