摘要
目的:从超微结构水平,观察三苯氧胺对蜕膜和绒毛超微结构的影响。方法:将停经40～45天的早孕妇女 9例,随机分 3组,正常对照组 3例,三苯氧胺组 3例(三苯氧胺,20mg,2次/日,x4天),三苯氧胺并米索组2例,于第5天阴道内置米索800μg。结果:三苯氧胺主要使大蜕膜细胞皱缩,粗面内质网肿胀,线粒体体积变小。蜕膜颗粒细胞中高电子密度颗粒减少,而绒毛合体滋养细胞则表现不同程度的退行性改变。并用米索后其对蜕膜及绒毛滋养细胞的损伤进一步加重。结论:三苯氧胺主要使大蜕膜细胞和合体滋养细胞发生退行性改变而起到抗早孕作用。
Objective: The ultrastructural changes of human decidua and chorion in early pregnancy were investigated after administration of Tamoxifen. Methods: 9 Women with gestational age of 40-45 days requesting induced abortion were devided randomly into three groups. 2 cases in control group,3 cases in Tamoxifen group were given Tamoxifen(20mg,Bid x4d)orally,2 cases in Tamoxifen plus misoprostol group were given misoprostol(800ug)intravaginally on the fifth day. Results:In Ta-moxifen group,the large decidual cells appeared shrunken,the rough endoplasmic reticula were tome-fied,the mitochondria got less,the decidval granular cells showed diminution of high electron density granula The syncytial trophoblast cells appeared degeneration in varying degrees,In Tamoxifon plus misoprostol group,the regressive changes in decidual and chorion became more serious Conclusion: Tamoxifen can induce the large decidual cells and syncytial trophoblast cells degeneration,and then disturb the maintennance of pregnancy.
出处
《中国计划生育学杂志》
2001年第6期343-345,共3页
Chinese Journal of Family Planning
