摘要
目的 :比较三种间断性人工重力对抗措施对模拟失重大鼠的影响。方法 :SD雄性大鼠 30只 ,按体重配对后随机等分为 5组 :对照组 (C) ,悬吊组 (S) ,站立组 (G1) ,1.5G(G2 )和 2 .6G人工重力组 (G3)。对抗组大鼠每日分别给予 1h的站立、1.5和 2 .6G人工重力作用。利用物理测量和三点弯曲等实验 ,观察了 3周间断性人工重力对大鼠股骨生长、生物力学特性的影响。结果 :与S组大鼠比较 :G1组弹性载荷、最大载荷和刚性系数显著恢复 (P <0 .0 5 ) ;G2组直径 (P <0 .0 1)和干重、密度 (P <0 .0 5 ) ,弹性载荷和最大载荷显著提高 (P <0 .0 5 ) ;G3组弹性载荷和最大载荷显著恢复 (P <0 .0 1)。结论 :三种对抗措施均显著改善了尾吊大鼠承重骨的生长力学特性 ,而 1.5G的
Aim: To explore the effects of three intermittent artificial gravity on simulated weightlessness rats. Methods: 30 male SD rats were divided into 5 groups: contro1 group (C), tai1 suspension group (S) and standing group (G1), 1.5 G group (G2), 2.6 G (G3) group; randomly and equally. G groups were given 1 h/d standing , 1.5 G or 2.6 G artificial gravity each day. The effects of 3 weeks artificial gravity on tail suspension rats were evaluated by measuring physical and mechanical parameters of femur. Results: Compared to S rats, elastic ultimate load (EUL), the ultimate load(UL) and bending rigidity coefficient (BRC) of G1 rats ( P <0.05) improved significantly; Diameter ( P <0.01), mass (dry) and density ( P <0.05), EUL and UL ( P <0.05) of G2 rats raised significantly; EUL and UL of G3 rats ( P <0.01) improved markedly. Conclusion: By using intermittent artificial gravity, the mechanical parameters of weight loading bones of simulated weightlessness rats were all improved apparently, and the one using 1.5 G 1 h/d artificial gravity was the best.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2001年第4期392-395,共4页
Chinese Journal of Applied Physiology
基金
全军医药卫生科研资金资助项目 ( 98Z0 83)
关键词
模拟失重
尾吊大鼠
人工重力
生物力学
股骨
simulated weightlessness
tail suspension
artificial gravity
biomechanics
