摘要
目的 :研究曲美他嗪 (Trimetazidine)对于处于常规治疗中的心肌梗死后的室性心律失常的作用。方法 :冠心病陈旧心肌梗死病例 (OMI) ,共 2 9对 (5 8例 ) ;男性 2 7对 ,女性 2对 ;配对主要条件 :性别、年龄、梗死部位、梗死后时间、高血压病史及分级 ;糖尿病史 ;采用病例配对、随机进入试验、交叉、单盲的试验设计 ;结果分析采用方差分析 (ANOV/F检验 )。结果 :综合交叉试验结果 ,Trimetazidine处理组室性心律失常的发生低于对照组(F =4 2 0 ,P <0 0 5 ) ;对于清醒时间段即活动时间段的室性心律失常的分析显示 :Trimetazidine也具有显著的抑制作用 (F =5 87,P <0 0 5 ) ;对于Lown3级以上室性心律失常的单独分析 ,也显示出其较明显的抑制作用 (F =7 6 1,P≈ 0 0 1) ;对于OMI后LVEF≤ 40 %患者组的室性心律失常 ,Trimetazidine也表现出明确的抑制作用 (F =5 43,P <0 0 5 )。结论 :对于陈旧性心肌梗死所伴发的室性心律失常 ,除基础药物的处理外 ,应用曲美他嗪可对其产生显著地抑制作用 ,并减少抗心律失常药物的应用 ;
Objective:For further comprehending the effects of the trimetazidine on the ventricular arrhythmia in old myocardial infarction patients Methods: total 58 cases (29 pairs) of coronary heart disease/old myocardial infarction patients/OMI were studied; the major matching limitations are: age, sex, infarcted section, infarcted time, hypertension or not (the grade),diabetes or not The study is randomized, pair matched, cross over and single blinded clinic study, the statistic analysis of variance (ANOV) was used Results: the incidence of ventricular arrhythmia was remarkably decreased in statistic difference( P <0 05)after be treated by trimetazidine ; and also decreased the incidence of the ventricular arrhythmia in activitiesperiod( P <0 05); For more severe ventricular arrhythmia (above the grade Lown3), the using of trimetazidine also showed more significant positive effects( P ≈0 01) Conclusion:for the ventricular arrhythmia accompany with OMI, in addition to the routine treatment, the trimetazidine could also play an important role, with the usage decreasing of other anti arrhythmia drugs
出处
《军医进修学院学报》
CAS
2001年第3期196-198,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
曲美他嗪
心肌梗死
心律失常
随机对照试验
trimetazidine
myocardial infarction
arrhythmia
tandomized controlled trials
