摘要
目的 探讨IL - 6及其受体、雌激素 (E2 )和骨丢失的关系 ,研究绝经后骨质疏松的病理机制。方法 以131名健康妇女作为研究对象 ,年龄 31～ 72岁 ,其中 6 4名未绝经者按年龄分组 ,6 7名绝经者按绝经年限分组。分别抽取静脉血分离血清检测E2 、FSH、IL - 6、sIL - 6R、sgp130、BGP、AKP、Ca、P等指标 ,同时测定腰椎及股骨颈骨密度 (BMD)。结果 E2 水平及BMD随年龄及绝经年限增加逐年下降 ,BMD和E2 呈正相关。IL - 6在绝经前含量较低 ,IL - 6、sIL - 6R和sgp130均有随年龄和绝经年限增加而上升的趋势 ,和E2 、BMD呈明显负相关。BGP和AKP绝经后各组明显高于绝经前各组 ,血钙水平于绝经早期有一过性增加 ,以后略有下降 ,并保持在一相对稳定水平。血磷各组变化不大。结论 妇女随着年龄增加 ,BMD逐年下降 ,特别是进入绝经期后 ,BMD下降速度加快。E2 水平下降可促进IL - 6及其受体的分泌 ,并进一步促使原始的破骨细胞 (osteoclast ,OC)发育、成熟和活化 ,促进骨吸收增加 。
Objective To investigate the effects of IL-6 and its receptors on bone loss in healthy women,and to assess the pathogenesis of the postmenopausal osteoporosis in women.Methods One hundred and one healthy women aged 31～72 including 64 sexual maturity women aged 31～52 were enrolled in four groups and 67 postmenopausal women,the years of menopause from 1 month to 23 years,were also enrolled in four groups.The bone mass of the lumbar-spine and femur were measured using dual-energy X-rays absorptionmetry;the serum E 2,FSH,BGP by radioimmunioassy(RIA);the serum IL-6,sIL-6R,sgp130 by ELISA;the serum AKP,calcium,phosphate by auto-biochemistry instrument.Results The BMD of lumbar-spine and right femur decreased following increase of age and the duration of menopause.Significant positive correlation was obserred between BMD and E 2,The serum IL-6,sIL-6R,sgp130 level was low,and stable before menopause.The level of IL-6,sIL-6R,sgp130 increased with variation of age and the duration of menopause.Significant negative correlation was observed between IL-6,sIL-6R,sgp130 and E 2,BMD.Serum AKP and BGP level was higher in postmenopausal women than that in sexiual maturity women.The serum calcium level increased significantly soon after menopausl,then decreased to the normal level The serum phosphate level had no difference in these groups.Conclusion The main cause of postmenopausal osteoporosis is the unbalance of the bone formation and resorption.
出处
《苏州医学院学报》
2001年第4期424-428,共5页
Acta Academiae Medicinae Suzhou
基金
卫生部科学基金资助课题 (卫 96 -2 -310 )
