摘要
目的 :观察强力宁 (QLN)对大鼠急性脑缺血再灌注损伤的作用。方法 :采用大鼠急性不完全性脑缺血再灌注损伤模型 ,测定脑组织含水量、丙二醛 (MDA)、超氧化物歧化酶 (SOD)及三磷酸腺苷酶 (ATPase)的含量。结果 :QLN(2 0mg·kg 1)能显著对抗缺血再灌注大鼠脑组织含水量、MDA含量的升高 (P <0 .0 5 ,P <0 .0 1) ,SOD及ATPase活性的降低 (P <0 .0 5 ,P <0 .0 1)。结论 :QLN具有保护脑缺血再灌注性损伤的作用 ,机制与降低脑脂质过氧化和增强氧自由基清除酶的活性 。
Objective: To observe the protective effects of Qianglining (QLN) against acute brain lesion induced by ischemia and reperfusion in rats. Methods:The contents of water, malondialehyde (MDA) and the activities of superoxide dismutase (SOD) and adenosinetriphosphatase (ATPase) in the brain tissue of mice were measured on the cerebral ischemia-reperfusion lesion model, which was produced by 30 minutes of common carotid artery ligation following 60 minutes of reperfusion in rats. Results:Qianglining significantly antagonized the increase of water and MDA contents (P<0.05 and 0.01, respectively) and the attenuation of SOD and ATPase activities in the brain tissue of rats treated with acute ischemia reperfusion (P<0.05 and 0.01, respectively). Conclusion:Qianglining has a protective effect against cerebral lesion induced by ischemia-reperfusion. It is speculated that this protective effect may be related to the inhibition of lipid peroxidation as well as the enhancement of SOD and ATPase activities.
出处
《医药导报》
CAS
2001年第7期407-408,共2页
Herald of Medicine
