摘要
为了探讨重组酵母乙型肝炎 (乙肝 )疫苗的免疫持久性 ,制定科学的免疫策略 ,有效控制乙肝提供依据。对1995年全程接种疫苗的儿童进行免疫后 5年的乙肝表面抗体 (抗 -HBs)和几何平均滴度 (GMT)水平追踪观察研究。结果显示 ,抗 -HBs阳性率和达保护水平率及GMT随儿童年龄的增长逐年下降 ,但抗 -HBs阳性率免疫后 5年仍保持在 81 19% ;抗 -HBs达保护水平率下降速率较快 ,免疫后 5年下降为 61 3 9%。根据本资料结果 ,从疫苗的免疫学保护水平考虑 ,免疫后 5年有必要考虑加强免疫。
In order to work out a scientific immune strategy for controlling hepatitis B,we made a survey to find out the immune persistence of yeast-derived recombinant hepatitis B vaccine immunized five years later.Children,who were HBsAg negative and have had received full course immunization of hepatitis B vaccine in 1995,were followed up for five years for anti-HBs and GMT detection.The results showed that the anti-HBs positive rates,anti-HBs protective rates and GMTs all declined along with age increasing.The anti-HBs positive rates declined not very quickly that still kept 81.19% five years later,but the anti-HBs protective rates reduced much more rapidly that fell to 61 39% five years later.According to this study,in consideration with the protection rate of the vaccine,it is necessary to give an enforced immunization five years later.
出处
《中国计划免疫》
2001年第4期198-199,共2页
Chinese Journal of Vaccines and Immunization
