摘要
对重组酵母乙型肝炎（乙肝）疫苗（ＹＤＶ，５μｇ／剂）的免疫效果、免疫持久性及保护效果进行了观察。应用０、１、２免疫程序免疫了６１３名６～９岁的小学生，分别接种了刀批ＹＤＶ，全程免疫后１个月，其血清抗－ＨＢｓ阳转率为９６％～１００％，总阳转率为９９％．ＹＤＶ的免疫持久性观察结果表明，每剂５μｇＹＤＶ和１０μｇ血源乙肝疫苗（ＰＤＶ）免疫后２年，其抗－ＨＢｓ≥１０ｍＩＵ／ｍｌ者均在９１％以上，两者无显著差异。乙肝母婴传播阻断的保护效果，用５μｇＹＤＶ免疫６５名ＨＢｓＡｇ及ＨＢｅＡｇ双阳性母亲所生婴儿，应用０、１、６免疫程序，全程免疫后７个月（１２月龄）在石家庄和横县两地区的保护率分别为％％及９２％。由此表明：ＹＤＶ免疫原性良好，可完全取代血源乙肝疫苗。
The immunogenicity of recombinant yeast-derived hepatitis B vaccine(YDV)wasevaluated in 613 healthy school children of 6~9 yearsoed. Three doses (5μg/dose) of YDVfrom 20 lots were given to childlen by 0,1 , 2 month schedule. The seroconversion rateof anti-HBs was 96% - 100%(overall 99%)at one month after the last vaccination. The durationof immunity of YDV (5μg/dose) was observed and compared to plasma-derived hepatitisB vaccinr(PDV, 10μg/dose). The percentages of anti-HBs level (≥10TnlU/nil) of both vaccineswere≥91% by 2 years after vaccination, and there was no significant difference betweenthem. All 65 infants, Whose mothers were both HBsAg and HBeAg positive, were immunizedwith three doses of YDV at 0, 1, 6 months of age after birth. The protective rates forpreventing prenatal transmission were 96% and 92% respeCtively at two investigated areas7 months after vaccination. These results showed that YDV has a satisfactory immunogenicityand can be accepted instead of PDV.
出处
《中国计划免疫》
1999年第3期158-161,共4页
Chinese Journal of Vaccines and Immunization
关键词
重组酵母
乙型肝炎疫苗
免疫原性
免疫持久性
Recombinant yeast-derived hepatitis B vaccine (YDV), Immunogeaicity,Immune persistence, Vaccine emcacy
