摘要
目的：探讨上皮钙粘附素（Ｅ－ｃａｄｈｅｒｉｎ，Ｅ－ｃａｄ．）及ａ连环素（ａ－ｃａｔｅｎｉｎ，ａ－ｃａｔ．）在肾癌组织中的表达及临床意义．方法：应用免疫组化方法对５１例肾癌组织中 Ｅ－ｃａｄ．及 ａ－ｃａｔ．的表达进行研究。结果：５１例肾癌组织中 Ｅ－ｃａｄ．及 ａ－ｃａｔ．的异常表达率分别为 ５０．９％和 ６０．８％，其中 ４６例肿瘤组织（ ９０．２％） 二者同时正常或异常表达，二者之间具有显著相关性（Ｐ＜０．０１）。Ｅ－ｃａｄ．及ａ－ｃａｔ．在肾癌组织中的异常表达率在肿瘤的病理分级和临床分期等方面差异具有显著性（Ｐ＜０．０５）。结论：Ｅ－ｃａｄ．及ａ－ｃａｔ．的异常表达在肾癌的恶性进展过程中起重要作用，二者均可作为判断肿瘤恶性程度及预后的指标．
Objective: To analyze the expression and clinical value of E-cadherin (E-cad) and Ecatenin (E-cat) in renal cell carcinoma (RCC). Methods: Immunohistochemical method was used to detect E-cad and E-cat expressions in 51 cases of RCC patients. Results: The abnormal expression rates of E-cad and E-cat were 50.9% and 60.8% in 51 cases respectively. E-cad and E-cat expressions were concomitantly either normal or abnormal in 90.2%$(46/51) of the tumors. The correlation between Ecad and E-cat expression was highly significant (p<0.0l). Both the gene expressions were related to the tumor grade, clinical stage and prognosis (P<0.05). Conclusion: Aberrant expression of E-cad and Ecat might play an important role in the malignant progression of RCC patients and could be used as a predictor of malignant potential and prognosis of RCC.
出处
《伤残医学杂志》
2001年第2期6-8,共3页
Medical Journal of Trauma and Disability
