摘要
目的研究上皮钙粘附素(epithelialcadherin,E-cad)在非小细胞肺癌(non-smallcelllungcancer,NSCLC)中的表达,探讨E-cad与NSCLC的组织类型、病理分级、TNM分期及淋巴结转移的关系。方法应用免疫组织化学SABC法检测65例原发性NSCLC,20例癌旁组织中E-cad蛋白的表达水平。结果20例正常肺组织均阳性表达,且均匀分布于膜表面。NSCLC中E-cad表达不均匀,阳性率为32.3%,与正常组比较差异有显著性(P<0.05)。但与组织类型无关(P>0.05),与病理分级、TNM分期及淋巴结转移显著相关(P<0.05)。结论E-cad与NSCLC的发生发展呈显著负相关,低表达者预示预后不良。
Objective To study the clinical significance of the expression of E-cad in patients with non-small cell lung cancer ( NSCLC ). Methods Immunohistochemical method (SABC) was used to detect the expression level of the E-cad in 65 NSCLC tissue and 20 normal lung tissue specimens .Results In normal lung tissue, the immunohistochemical staining of E-cad protein was mainly located in the surface with the positive rate of 100%. In NSCLC, the expression of E-cad was not even with the positive rate of 32.3%. E-cad protein expression was found to be significant differences (P<0.05) in the NSCLC compared with normal lung tissue. Its expression was not related to the histological type (P>0.05), The expression of E-cad was related to pathological grades, TNM stages and lymph node metastasis (P<0.05). Conclusion E-cad played an important role in the malignant progression in NSCLC, and may be used as maker for malignant potentcy and prognosis of NSCLC.
出处
《现代肿瘤医学》
CAS
2005年第4期482-483,共2页
Journal of Modern Oncology
