摘要
动脉粥样硬化病 (AS)是一种具有慢性炎症反应特征的病理过程。血管内皮细胞在引发和扩大动脉炎症反应中起了关键的作用。以NF κB转录因子家族为调控中心的内皮细胞活化及炎症基因诱导途径有可能成为有关危险因子促动脉粥样硬化形成的的共同途径。选择性保护内皮细胞 ,调节内皮细胞的炎症反应 。
The accumulated evidence indicated atherosclerosis (AS) is associated with a chronic inflammatory reaction. Either by secretion of inflammatory mediator or by modulation of expression of adhesive molecules onvascular surface, vascular endothelial cells play a key role in initiation and amplification of inflammation in artery. The NF κB transcription factor family is a pleiotropic regulatory of endothelial cells activation and the multiple genes relevant inflammatory cytokines are regulated by NF κB transcriptional activation in endothelial cells. Selective protection of vascular endothelium and regulation of endothelial inflammation may be rational as the target for anti AS.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2001年第4期361-364,共4页
Chinese Pharmacological Bulletin
