摘要
目的探讨血管紧张素Ⅱ受体拮抗剂氯沙坦对兔动脉粥样硬化的影响及机制。方法 32只新西兰大白兔适应性喂养1周后随机分为正常对照组、高脂组和氯沙坦组,观察各组药物干预前后体重、血脂、血管紧张素Ⅱ及炎症指标的变化。结果动脉粥样硬化模型建立后,高脂组和氯沙坦组血脂、白细胞介素6及C反应蛋白水平高于正常对照组(P<0.05),但高脂组和氯沙坦组之间无统计学差异。药物干预8周后,氯沙坦组白细胞介素6和C反应蛋白水平低于高脂组(P<0.05),但氯沙坦组和高脂组血脂、白细胞介素6和C反应蛋白水平高于正常对照组,氯沙坦组与高脂组之间血脂水平无统计学差异。氯沙坦组和高脂组内膜/中膜厚度比值较正常对照组增大,氯沙坦组内膜/中膜厚度比值较高脂组减小(P<0.05)。氯沙坦组和高脂组血管紧张素Ⅱ水平较正常对照组增高(P<0.05),但高脂组与氯沙坦组之间无统计学差异。结论氯沙坦具有抗动脉粥样硬化作用,该作用与脂质代谢无关,与抑制动脉粥样硬化过程中的炎症反应密切相关。
Aim To investigate the effect and mechanism of losartan on atherosclerosis in rabbits. Methods 32 New Zealand rabbits were randomly divided into three groups： control group, high-cholesterol group and losartan group. The level of weights, lipids and inflammatory factors, such as interleukin-6 （ IL-6 ） and C-reactive protein （CRP） were detected before the losartan intervention and two months after the losartan intervention respectively. The content of angiotensin Ⅱ （ Ang Ⅱ ） was detected on later stage of the experiment. Pathological examination was performed on the ratio of intima thickness to media thickness of the iliac arteries. Results After the atherosclerosis model was set up, the serum lipids and CRP, IL-6 of rabbits in high-cholesterol group and losartan group rised significantly compared to the control group, but there was no statistical difference between two groups. After the losartan intervention, serum CRP, IL-6 were higher in high- cholesterol group and losartan group compared to the control group, but lower in losartan group. Serum lipids of rabbits in high-cholesterol group and losartan group also rised significantly compared to the control group, but there was no statistical difference between them either. The ratio of intima thickness to media thickness were higher in high- cholesterol group and losartan group compared to the control group （ P 〈 0.05 ） , but the ratio in losartan group was lower than high-cholesterol group. Angiotensin Ⅱ was higher in high-cholesterol group and losartan group compared to the con- trol group. But there was no statistical difference between them. Conclusion Losartan can prevent the development of atherosclerosis due to its action of inhibiting inflammation and the effect of losartan on atherosclerosis may not be related to the lipid metabolism.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2010年第6期377-380,共4页
Chinese Journal of Arteriosclerosis
