摘要
目的 研究芪归花宁心冲剂对多种原因所致心肌损害的影响。方法 连续给予动物芪归花宁心冲剂一周后，观察该药对垂体后叶素（０．５Ｕ／ｋｇ，ｉｖ）、异丙肾上腺素（１０ｍｇ，ｉｃ）所致心肌缺血，以及氯化钡（２０ｍｇ，ｉｖ）所致心律失常的影响；采用柯萨奇马病毒（ＣＢ３病毒）攻击动物心脏后再连续给予受试药７、１４ｄ和２８ｄ，观察芪归花宁心冲剂对动物体内病毒中和抗体含量、病毒滴度及心肌病理学改变的影响。结果 芪归花宁心冲剂各剂量组均可明显对抗垂体后叶素、异丙肾上腺素的致心肌缺血作用和氯化钡的致心律失常作用；可提高动物体内中和抗体水平，降低病毒毒力，减轻病毒对心脏的的损害。结论 芪归花宁心冲剂对心肌缺血和ＣＢ３病毒致心肌损害作用具有防治性保护作用。
Objectives To investigate the effects of Qiguihua Ningxin Granules on myocardial damage caused by several factors. Methods After Qiguihua Ningxin Granules being used consecutively for one week, we investigated its effects on the pituitrin-induced and isoprenaline-induced myocardial ischemia, and its effects on barium chlo-ride-induced arrhythmia in animals. Its effects on Coxsackie B3 virus(CB3)-induced myocardial damage were also studied by giving Qiguihua Ningxin Granules consecutively for 7, 14 and 28 days immediately after the animals were challenged by CB3. Results Different doses of Qiguihua Ningxin Granules had significant protective effects on pituitrin-induced and isoprenaline-induced myocardial ischemia. Its protective effcts on barium chloride-induced arrhythmia were also significant. Besides, it could elevate the animal's neutralizing antibodies, weaken the virulence of the CB3 virus, and reduce the myocardial damage caused by CB3 virus. Conclusion Qiguihua Ningxin Granules had prophylactic and therapeutic effects on myocardial ischemia and CB3-induced myocardial damage.
出处
《中国地方病防治》
CAS
2001年第4期204-206,共3页
Chinese Journal of Control of Endemic Diseases
关键词
芪归花宁心冲剂
心肌缺血
心律失常
中医药疗法
治疗
实验研究
Traditional Chinese Drug Qiguihua Ningxin granules Myocardial ischemia Arrhythmia Coxsackie B_3 virus
