摘要
目的 研究转化生长因子 β1 (TGFβ1 )和肿瘤坏死因子 α(TNFα)在门静脉高压症 (门脉高压 )发病中的作用。 方法 应用酶联免疫分析方法对 5 0例门脉高压患者 (其中 2 0例伴腹水形成 )、5 0例正常对照者进行TGFβ1 和 TNFα的检测。 结果 对照组血清 TGFβ1 和 TNFα为 12 .32± 3.2 9ng/ml,94.74± 49.30 pg/ml,门脉高压组分别为 19.2 1± 5 .87ng/ml,140 .85± 5 3.47pg/ml(P<0 .0 5 ) ;门脉高压伴腹水者为 18.44± 5 .89ng/m l,16 7.34± 38.6 2 pg/ml,不伴腹水者为 2 0 .6 8± 6 .73ng/ml,10 1.5 4± 2 8.2 4pg/m l,两者比较 TGFβ1 差异无显著性 ,而有腹水者 TNFα高于无腹水者 (P<0 .0 5 )。 结论 TGFβ1 和 TNFα水平升高在肝硬化门脉高压发病的病理生理机制中起作用。
Objective\ To study the pathogenetic effects of transforming growth factor beta(TGFβ\-1) and tumor necrosis factor α(TNFα) in patients with portal hypertension.\ Methods\ The levels of TGFβ\-1 and TNFα were assayed by enzymed linked immunosorbent assay(ELISA) from 50 patients with portal hypertension and 50 controls, 20 samples of ascitis from the patients were also detected.\ Results\ The levels of TGFβ\-1 and TNFα in patients with portal hypertension were 19 21±5 87 ng/ml and 140 85±53 47 pg/ml, respectively.\ The levels of normal control were 12 32±3 29 ng/ml and 74 94±25 30 \{pg/ml\}, respectively.\ The levels in patients with ascitis were 18 44±5 89 ng/ml and 167 34±38 62 \{pg/ml\}, respectively, while the levels in patients without ascitis were 20 08±4 73 ng/ml and 101 54±28 24 pg/ml, respectively.\ The levels of TGFβ\-1 and TNFα in patients were higher than those of normal(P<0 05), the level of TNFα in patients with ascitis was higher than that of without ascitis(P<0 05).\ \{Conclusion\}\ TGFβ\-1 and TNFα play an important role in the pathogenesis of portal hypertension.
出处
《福建医科大学学报》
2001年第2期142-143,共2页
Journal of Fujian Medical University
基金
福建省自然科学基金资助项目!( C960 42 )
