期刊文献+

正常供体外周血干细胞动员和采集的初步研究

Primary Study for Mobilization and Collection of Peripheral Blood Stem Cells in Normal Donors
下载PDF
导出
摘要 目的 探索正常供体外周血干细胞动员方法和采集结果。方法 对 3例拟做异基因干细胞移植的HLA相合的同胞姐妹进行G -CSF动员 ,剂量为 30 0 μg ,每日 2次皮下注射 ,并做临床及实验指标的动态观察。 结果  1例于动员后第 4天采集 1次 ,另 2例于第 4、5天各采集 1次 ,获足量CD34 + 细胞用于移植 ,副作用可耐受 ,未见远期不良反应。结论 G -CSF动员正常供体安全有效。 Objective To explore the mobilization and collection of peripheral blood stem cells in normal donors.Methods G-CSF 300 μg twice daily for 4 to 5 days for three HLA-identical sibling donors.Results All three collection were successful,one through 1 apheresis the other two by 2 apheresis. The side-effects were tolerable.Conclusion The mobilization by G-CSF administration is efficient and safe for normal donors.
出处 《苏州医学院学报》 2001年第3期276-277,共2页 Acta Academiae Medicinae Suzhou
  • 相关文献

参考文献7

  • 1[1]Gratwohl A,Passweg J,Baldomero H,et al.Blood and marrow transplantation activity in Europe 1996[J].Bone Marrow Transplant,1998,22∶227~239 被引量:1
  • 2[2]Russell NH,Hunter A,Rogers S,et al.Peripheral blood stem cells as an alternative to marrow for allogeneic transplantation[J].Lancet,1993,341∶1482~1489 被引量:1
  • 3[3]Grigg AP,Roberts AW,Raunow H,et al. Optimizing dose and scheduling of Filgrastim (granulocyte colony-stimulating factor)for mobilization and collection of peripheral blood progenitor cells in normal volunteers[J].Blood,1995,86∶4437~4442 被引量:1
  • 4[4]Bensinger WI,Weaver CH,Appelbaum FR,et al.Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colonystimulating factor[J].Blood,1995,85∶1655~1662 被引量:1
  • 5[5]Korbling M,Huh YO,Durett A,et al.Allogeneic blood stem cell transplantation∶peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+Thy-1dim) and lymphoid subsets,and possible predictors of engraftment and graft-versus-host disease [J].Blood,1995,86∶2842~2850 被引量:1
  • 6[6]Harada M.Allogeneic peripheral blood stem cell transplantation is coming of age[J].Internat J hematol,1995,62∶1~6 被引量:1
  • 7[7]Tabilio A,Falzetti F,Giannoni C,et al.Stem cell mobilization in normal donors[J].J Hematother,1997,6∶227~236 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部