摘要
目的 :比较头孢曲松、头孢克肟治疗下呼吸道感染的安全、有效性及经济学意义。方法 :选择 10 0例下呼吸道感染患者 ,随机分为头孢曲松、头孢克肟序贯治疗组 (A组 ) ,单用头孢曲松组 (B组 )。每组受试 5 0例 ,A组使用头孢曲松 1g ,静滴 ,bid ,疗程 7d ,病情缓解后 ,转换为头孢克肟胶囊 2 0 0mg ,口服 ,bid ,再治疗 7d。B组单用头孢曲松 1g ,静滴 ,bid ,疗程 14d。比较两种治疗方法的差异。结果 :A组临床疗效和细菌清除率分别为80 .0 % ,76 .0 % ;B组临床疗效和细菌清除率分别为 86 .0 % ,75 .0 %。两组比较差异不显著 (P >0 .0 5 )。两组不良反应均轻微。结论 :头孢曲松、头孢克肟序贯治疗疗效确切可靠、经济、方便。
Objective: To evaluate and compare the efficacy, safety and economy of ceftriaxone-cefixime sequential therapy and ceftriaxone-only protocol in the treatment of adult patients with lower respiratory tract infection. Method: 100 patients with lower respiratory tract infection were randomly assigned to one of the two treatment groups: The group A received ceftriaxone 1g iv twice a day for 7 days, then followed by cefixime 200 mg twice a day for 7 days, and group B was given ceftriaxone 1 g iv twice a day for 14 days. Clinical observation was made once a day and laboratory tests including bacteriological tests and chest X-ray film were conducted before and after the study. Results: 100 Patients (50 subjected to ceftriaxone-cefixime sequential therapy, 50 to ceftriaxone only therapy) were evaluated for clinical efficacy, safety and economy of the therapies. The total duration of treatment for two groups was 14 days. The clinical effective rate of ceftriaxone-cefixime sequential therapy and control(ceftriaxone-only) group were 80%, and 86% respectively and the bacterial eradication rates were 76% and 75% respectively. Conclusion: The results indicated that the ceftriaxone-cefixime sequential therapy was effective, safe and cost-effective in the treatment of patients with lower respiratory tract inection.
出处
《药物流行病学杂志》
CAS
2001年第2期57-58,共2页
Chinese Journal of Pharmacoepidemiology
关键词
头孢曲松
头孢克肟
序贯治疗
下呼吸道感染
Ceftriaxone
Cefixime capsule
Sequential therapy
Lower respiratory tract infection
