摘要
目的研究载脂蛋白 E(Apo E)基因多态性与中国人群冠心病的关联。方法选择 6 3例冠心病患者及年龄、性别相匹配的 90例正常对照组 ,聚合酶链反应 -限制性片段长度多态性 (PCR- RFL P)方法检测 Apo E基因型。比较两组基因型及等位基因频率分布。结果冠心病组 ε4等位基因频率 (12 .70 % )明显高于对照组 (5 .5 5 % ) (P<0 .0 5 )。结论
Objective To detect the relationship of Apolipoprotein E (ApoE) polymorphism with coronary heart disease(CHD).Methods ApoE genotypes of 63 cases with CHD and 90 cases of control were detected by PCR RFLP.ApoE genotypes and alleles frequencies were compared.Results The frequencies of ε 4 allele in patients with CHD(12 70%) was higher than that in control subjects(5 55%)( P <0 05).Conclusion Apo ε 4 allele is probably the genetic marker of CHD.\;
出处
《中国慢性病预防与控制》
CAS
2001年第3期109-110,121,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
载脂蛋白E
基因
聚合酶链反应
限制性片段长度多态性
冠状动脉疾病
Apolipoprotein E
Gene
Polymerase chain reaction
Restriction fragment length polymorphism
Coronary heart disease
