摘要
目的 :研究四氢帕马汀 (THP)对大鼠海马缺血再灌注损伤的保护作用。方法 :利用结扎颈总动脉造成大鼠急性脑缺血再灌注模型 ,观察THP对大鼠海马缺血再灌注损伤的保护作用。结果 :THP能使脑缺血再灌注过程中海马组织超氧化物歧化酶 (SOD)活力 (P <0 .0 1)和谷胱甘肽过氧化物酶 (GSHPx)活力明显升高 (P <0 .0 5 ) ,脂质过氧化产物丙二醛 (MDA)明显下降 (P <0 .0 1) ;同时使细胞膜上Na+ K+ ATP酶和Ca2 + Mg2 + ATP酶活力升高 (P <0 .0 5 )。结论 :THP对脑缺血再灌注损伤有保护作用。
Objective: To study the protective effects of tetrahydropalmatine (THP) against ischemia-reperfusion induced hippocamp lesion in rats. MethodS: A model of ischemia-reperfusion induced brain lesion was set up by ligation of common carotid arteria in rats, and the protective effects of THP was observed. Results: It was found that, with administration of THP, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and Na+, K+-ATPase as well as Ca 2+-ATPase were increased (P<0.05, respectively), while malondialehyde (MDA) was decreased to 42.5% (P<0.01) during brain ischemia-reperfusion. Conclusion:The results suggested that THP can protect the rat against ischemia-reperfusion induced brain lesion.
出处
《医药导报》
CAS
2001年第5期284-285,共2页
Herald of Medicine
