摘要
目的 :提取分离穿心莲抗血小板聚集活性物质。方法 :用有机溶剂萃取、化学分离和硅胶柱层析法对穿心莲抗血小板聚集部位逐级分离 ,同时用样本对ADP诱导的血小板聚集抑制作用作活性比较 ,筛选出活性强的组份继续分离。结果 :氯仿提取部位中的酸性组份 (F0 2 1)有较强的抗血小板聚集活性 ,且其中F0 2 12 和F0 2 14 组份可用作分离抗血小板聚集的单体化合物。结论
Objective:This paper was designed to reveal the active ingredients to inhibit platelet aggregation in Andregraphis Paniculata Ness (APN). Methods:Separating the active component parts of APN on the antiplatelet aggretion by extraction of organic solvent, chemical separation and silica column chromatography step by step, simultaneously comparing the effect of samples in APN on the antiplatelet aggretion induced by ADP, so that we can find the more active components. Results:We find the acid components in chlorlform parts (F 021 ) show more active on the antiplatelet aggretion, farthermore we think we can obstain pure chemicals on the antiplatelet aggretion in F 0212 and F 0214 . Conclusions:The active components on antiplatelet aggretion of APN can be prepared by separation step by step.
出处
《医药导报》
CAS
2001年第1期6-7,共2页
Herald of Medicine
基金
国家自然科学基金资助课题! (NO .3970 859)
