摘要
目的观察癫痫患者的免疫功能状态。方法检测了２８例癫痫患者外周血单个核细胞（ＰＢＭＣ）培养上清液的ＴＮＦα水平，测定了血清ｓＩＬ－２Ｒ，并与２５例对照组进行比较。结果癫痫患者ｓＩＬ－２Ｒ和ＴＮＦα显著高于对照组，其与病因、癫痫类型、服药及脑电图无关，但ＴＮＦα与病程有关。结论癫痫患者免疫功能低下，体内淋巴细胞处于活化状态。
Objective To observe the status of immune function in the patients with epilepsy. Methods The immunologic aspects of 28 epileptic patients were evaluated.TNFalpha levels of semens by PBMCS were evaluated,the serum sIL-2R was also measured and was compared with 25 healthy persons .Resaults It was found that the concentions of sIL-2R and TNFalpha of the epilptic patients were significantly higher than the control group,not being related to etiology,attacking type,EEG or whether anticonvulsants had been taken.But TNFalpha was related to the course of disease.Conclusion It is indicatecd that immune function in epileptic patients is impaired,and the lymphocytes are in a status of being highly activated,the activated lymophocytes produce more TNFalpha which may play an important role on the pathogonesis of epilepsy.
出处
《临床神经病学杂志》
CAS
1998年第4期213-215,共3页
Journal of Clinical Neurology
