摘要
目的 研究人非小细胞肺癌中p73基因的mRNA表达状况 ,并探讨其表达水平与肿瘤各项临床病理指标间的相关性。方法 应用半定量RT PCR方法检测人非小细胞肺癌组织、相应癌旁肺组织及远癌肺组织中p73的mRNA表达。结果 p73基因的表达水平及表达阳性率在肺癌组织中为 87.5 % (2 8/32 )明显高于相应的癌旁肺组织和远癌肺组织 (P <0 .0 1) ;不同临床病理学类型、分化程度及TNM分期的肺癌组织间p73mRNA的表达差异无显著性 (P >0 .0 5 )。结论 p73基因在人非小细胞肺癌组织中的表达显著上调。
Objective To study the expression of p73 in human non small cell lung cancer (NSCLC) and the relationship between p73 expression and clinico pathological parameters. Methods Expression of p73 gene was detected by RT PCR in 32 human NSCLC tissues, tissues adjacent to cancer and non cancer lung tissues. Results p73 gene expression up regulated substantially and detected in 87.5%(28/32) of human NSCLC tissues while expressed at low level in tissues adjacent to cancer and non cancer lung tissues. Conclusion Marked up regulation of p73 gene expression is found in human NSCLC.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2001年第5期536-538,共3页
Journal of Third Military Medical University
基金
重庆市应用基础基金资助项目! ( 99-5658)
