摘要
神经元特殊形态的形成及维持主要依赖于神经元细胞骨架中微管的装配。在此过程中，涉及到微管的组成及其动力学性质，而最终形成了稳定的微管结构。在神经元中，这一结构为沿着神经突运输物质提供了基础。本文将主要在神经无微管的结构与功能，神经元微管蛋白异构基因的表达及其翻译后加工形式等方面的研究进展加以综述。
The formation and maintenance of the characteristic sharp of neurons mainly relies on the assembly of an organized microtubule array that is the predominant component of the neuronal cytoskeleton. During this process there is an evolution in the composition and dynamics of microtubules, resulting in stable microtubule bundles that provide structural support and function in intracellular transport along the neurites. In this essay we provide an overview of structure and function relating neuronal microtubules in neurons with particular attention to the roles of multiple tubulin isogenes expression and posttranslational modifications of tubulin.
出处
《生命科学》
CSCD
2001年第2期70-73,63,共5页
Chinese Bulletin of Life Sciences
关键词
神经元微管
神经元微管蛋白
翻译后加工
neuronal microtubules
neuronal tubulins
posttranslational modification
