摘要
本文观察了rHuTNF-α对ConA诱导的10～15日龄BALB/C乳鼠胸腺细胞、脾细胞以及PHA或TPA诱导的20～32周龄人胚胸腺细胞增殖的调节作用。结果表明:rHuTNF-a对上述增殖作用均有显著的促进作用,并且呈剂量依赖关系;rHuTNF-a对rHuIL-2促进ConA诱导的小鼠胸腺细胞和脾细胞的增殖反应有协同作用。此结果提示rHuTNF-a在促进丝裂原诱导的胸腺细胞增殖作用中无明显种属特异性,并且对于了解TNF-a在胸腺细胞发育中的作用以及在某些病毒性感染疾病患者血清中高水平的TNF-a活性与胸腺功能改变的关系方面均有一定的意义。
The capacity of recombinant human tumor necrosis factor-α (rHuTNF-α) to modulate mitogen-induced human fetal thymocyte or murine thymocyte proliferation was investigated. rHuTNF-a augmented, in dose dependent manner, PHA-or TPA-stimula-ted human thymocyte proliferation or ConA-induced murine thymocyte and splenoeyte proliferation. Also, rHuTNF-α enhanced the ConA-stimulated murine thymocyte and' splenoeyte response to exogenous rIL-2. The results demonstrated that TNF-α enhancement showed no obvious species preference in vitro. These data suggested that TNF-α might play an immunoregulatory role in thymocyte development.
出处
《上海免疫学杂志》
CSCD
北大核心
1991年第6期321-323,共3页
Shanghai Journal of Immunology
