摘要
本文观察了CD3 McAb 对PHA 和TPA 诱导的20～36周龄人胚胸腺细胞增殖反应的调节作用。结果表明:CD3McAb 不能单独诱导人胚胸腺细胞增殖反应,但却能显著地促进TPA 诱导的人胚胸腺细胞增殖和抑制PHA 诱导的人胚胸腺细胞增殖,并呈剂量依赖关系;加入外源性rHulL—2能促进人胚胸腺细胞对CD3McAb 诱导的应答反应,而rHuIL—1则无此作用。此结果对于了解人胚胸腺表达CD_3抗原细胞的功能水平及CD_3分子的生物学作用有一定的意义.
The regulatory effect of CD3 McAb on the human fetal thymocyte proliferative response toTPA was investigated.It was shown that the CD3 McAb couldn't induce human fetal thymo-cyte proliferative response,but suppressed PHA-induced human fetal thymocyte proliferativeresponse and promoted TPA-induced proliferative response,in a dose dependent manner.Ex-ogenous rHuIL—2,but not rHuIL—1 ,could enhance the proliferative response to CD3 McAb.These results have significances for understanding the expression of CD3 antigen and it's func-tions.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1993年第1期7-9,共3页
Chinese Journal of Immunology
关键词
细胞因子
单克隆抗体
抗原
胸腺
cytokine
monoclonal antibody
thymocyte
proliferation
