摘要
目的:探讨趋化因子受体(CCR)4与叉头框转录因子Foxp3调节性T细胞在不同临床分期蕈样肉芽肿(MF)患者皮损中的表达,并初步探讨其意义。方法:收集22例MF患者的皮损组织,采用免疫组化方法,分别检测CCR4与Foxp3的表达水平。结果:Foxp3在MF斑块期表达明显增多,红斑期次之,而在肿瘤期几乎不表达;尽管CCR4在各期MF中均有表达,但其表达程度以红斑期最强,斑块期次之,肿瘤期最弱,差异有统计学意义(P<0.001),且CCR4与Foxp3在皮损中的阳性表达存在正相关关系(相关系数为0.489)。结论:CCR4与Foxp3在不同分期MF皮损中的表达对了解MF免疫功能的变化和新的治疗提供帮助。
Objective： To investigate the expression of CC chemokine receptor （CCR） 4 and Foxp3＋ regulatory T cells （Tregs） in different stages of mycosis fungoides （MF） and subsequently explore their significance for the development of MF. Methods： Tissue specimens were obtained from the lesions of 22 patients with MF. Immunohistochemistry was performed to detect the expression of CCR4 and Foxp3 in the tissue specimens. Results： Immunohistochemieal staining showed that the ex- pression of Foxp3 in the plaque stage was significantly increased compared to the erythematous stage and hardly any expression observed in the tumor stage. Although CCR4 were expressed in all groups, the positive rate showed obvious difference, higher in erythematous lesions, median in plaque and lower in tumor lesions（P〈0.001）. Furthermore, expression of CCR4 had a positively correlated with expression of Foxp3＋ Tregs in MF lesions（correlation factor=0.489）. Conclusions： The results indicate that the expressions of CCR4 and Foxp3 in the different stages of MF may help us better understanding the immunologic changes, and providing new ideas for treatment of MF.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2014年第7期389-392,共4页
Journal of Clinical Dermatology
