摘要
目的了解青海藏族与汉族酒精性肝病人群中乙醛脱氢酶2(ALDH2)基因多态性分布及与酒精性肝病的关系。方法以聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对不同组人群的ALDH2基因型进行检测并比较其基因频率。结果藏族与汉族酒精性肝病患者等位基因ALDH2*2均低于健康对照组。结论 ALDH2基因与本地区酒精性肝病的易感性有关,ALDH2*2等位基因可能是ALD发生的负性因子。
Objective To study the relationship between the polymorphisms of alcohol - metabolizing ALDH2 loci among the Tibetan and Hart population and alcoholic liver disease （ALD）in Qinghai. Methods Techniques of polymerase chain reaction- restriction fragment length polymorphism（ PCR- RFLP）was used to detect the genotypes of ALDH2, in different groups. Results Frequencies of ALDH2 ＊ 2 alleles was lower in Tibetan or Han ALD patients than that of health groups. Conclusion ALDH2 are associated with ALD, and ALDH2 ＊ 2 alleles is the negative factor of ALD .
出处
《青海医学院学报》
CAS
2014年第2期92-94,共3页
Journal of Qinghai Medical College
