摘要
目的探讨不同程度脑白质疏松症(LA)患者认知功能障碍的特点。方法将符合LA影像学诊断标准的150例患者按Aharon-peretz标准由轻到重分成4组,其中LA-1组45例,LA-2组38例,LA-3组36例,LA-4组31例,并设健康对照组35例;分别用简易智力状态量表(MMSE)、日常生活能力量表(ADL)/Barthel指数进行评估,通过统计分析判断各组之间认知功能及日常生活能力是否存在统计学差异。结果随着LA严重程度的增加,MMSE评分及Barthel指数逐渐降低;其中LA-1、LA-2组与对照组比较,差异无统计学意义(P>0.05);而LA-3、LA-4组与对照组比较,差异有统计学意义(P<0.05),其中记忆力、注意力和计算力及日常生活能力的下降更明显(P<0.01)。结论随着LA严重程度的增加,患者的认知功能障碍程度及日常生活能力下降的程度也逐渐增加,因此认知功能障碍和日常生活能力可作为监测LA患者病情的重要指标。
Objective To explore the characteristics and degrees of cognitive impairment in the patients with different degrees of leukoaraiosis（LA）.Methods 150 patients with LA were divided into 4 groups from mild to severe according to the severity of Aha-ron-peretz standard：LA-1 group （45 cases）,LA-2 group（38 cases）,LA-3 group（36 cases）and LA-4 group（31 cases）,and 35 healthy subj ects were selected as the control group.The mini-mental state examination scale （MMSE）and the activities of daily living （ADL）Barthel index were adopted for evaluation.The statistical differeces in the cognitive function and the activity of daily living among the groups were j udged by the statistical analysis.Results The MMSE scores and the Barthel index were gradually decreased with the LA severity degree increase;there were no statistically significant differences between the LA-1 and LA-2 groups with the control group（P〉0.05）,however,there were statistically significant differences between the LA-3 and LA-4 groups with the control group（P〈0.05）,in which the decrease of the memory,attention,calculating ability and activity of daily living were more significant（P〈0.01）.Conclusion The decreased degrees of cognitive impairment and the daily living ability are increased with the LA severity degree increase.Therefore,the cognitive impairment and the daily living ability may be used as the important indexes for monitoring the condition of LA patients.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第17期2132-2133,2136,共3页
Chongqing medicine
关键词
脑白质疏松症
认知功能
简易智力状态
日常生活能力
leukoaraiosis
cognitive-function
mini-mental-state-examination
activities-of-daily-living
