摘要
目的和方法 :采用电生理学技术观察一氧化氮 (NO)和心房钠尿肽 (ANP)对肾动脉内注射内皮索 (ET)所致麻醉大鼠肾神经传入放电 (RANA)的影响。结果 :①肾动脉内注射ET 1后平均动脉压 (MAP)先有短暂的降低随后为较显著的持久增高 ,RANA明显增加 ;②肾动脉内分别注射NO前体L Arg和ANP后 ,ET 1的上述效应即被阻抑。结论 :肾动脉内注射ET 1引起RANA明显增加 。
Aim and methods: By using electrophysiological technique, the effects of nitric oxide (NO) and atrial natriuretic peptide (ANP) on renal afferent nerve activity (RANA) induced by intrarenal arterial injection of endothelin 1(ET 1) were examined in anesthetized rat. Results: (1) In response to intrarenal arterial injection of ET 1 (1μg/kg)MAP was initially decreased and subsequently increased, and RANA was increased to 208.33±16.60%( P <0.001). (2)Pretreatment with L Arg or ANP could effectively inhibit the above biological actions induced by ET 1. Conclusion: Intrarenal arterial injection of ET 1 can markedly induce the increase in RANA, an effect which is abolishd by L arg or ANP administered by the same route.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2001年第1期34-36,共3页
Chinese Journal of Applied Physiology
基金
河北省自然科学基金资助项目!(395 42 0 )
关键词
内皮素
一氧化氮
精氨酸
心房钠尿肽
肾神经传入放电
endothelin
nitric oxide
L arginine
artrial natriuretic peptide
renal afferent nerve activity
