摘要
目的:探讨4种给药方案治疗妊娠期假丝酵母菌阴道炎的经济学效果。方法:按用药情况不同,将215例妊娠期假丝酵母菌阴道炎患者分为A、B、C、D组。所有患者每晚用水清洗外阴后将药物置于阴道后穹窿,A组给予制霉素阴道栓1枚,7 d为1个疗程;B组给予复方莪术油栓1枚,6 d为1个疗程,共2个疗程;C组给予克霉唑阴道片1片,第4天再重复1次,共2个疗程;D组给予硝呋太尔制霉素阴道软胶囊1枚,6 d为1个疗程。均于停药7 d后到门诊妇科复查,观察各组的疗效和不良反应,并进行成本-效果分析。结果:A、B、C、D组成本分别为127.75、131.00、193.30、146.15元,总有效率分别为78.43%、83.33%、92.73%、96.36%,成本-效果比分别为162.88、157.21、208.45、151.67,B、C、D组相对于A组的增量成本-效果比分别是66.33、458.39、102.62。结论:D组方案治疗妊娠期假丝酵母菌阴道炎较佳。
OBJECTIVE： To explore the pharmacoeconomic effectiveness of 4 kinds of therapeutic regimes for vaginal candidiasis during pregnancy. METHODS： 215 patients in pregnancy with vaginal candidiasis were divided into group A, B, C and D according to the situation of drug use. Every night drug was placed in the posterior fornix after washing vulvar with water, and the drug administered in different groups were as follows： Nysfung vaginal suppositories, one tablet daily, 7 days as treatment course （group A） ; Compound zedoary turmeric oil suppositories, one tablet daily, 6 days as treatment course, for 2 treatment courses （group B）; Clotrimazole vaginal tablets, one tablet every four days, for 2 treatment courses （group C）; Nysfung vaginal soft capsules, one tablet daily, 6 days as treatment course （group D）. At 7th day after drug withdrawal, therapeutic efficacy and adverse reactions were observed, and cost-effectiveness was analyzed. RESULTS： The costs of group A, B, C and D were 127.75 yuan, 131.00 yuan, 193.30 yuan and 146.15 yuan, respectively; total effective rates were 78.43%, 83.33%, 92.73% and 96.36%, re,spectively; cost-effectiveness ratios were 162.88, 157.21, 208.45 and 151.67, respectively; as compared with group A, the incremental cost-effectiveness ratio of group B, C and D were 66.33, 458.39 and 102.62, respectively. CONCLUSIONS： Compared with the other groups, group D has better cost-effectiveness for vaginal candidiasis during pregnancy.
出处
《中国药房》
CAS
CSCD
2014年第26期2404-2406,共3页
China Pharmacy
