摘要
目的了解大黄蟅虫胶囊联合卵磷脂治疗高脂血症合并非酒精性脂肪肝(NAFLD)伴谷丙转氨酶升高(ALT)患者的疗效和安全性。方法将符合高脂血症合并NAFLD伴ALT升高的117例患者随机分为大黄蟅虫胶囊联合卵磷脂治疗组和常规药物治疗对照组,用药后观察总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及ALT情况。结果治疗后治疗组ALT、TC、TG及LDL-C值均明显低于治疗前,差异有统计学意义(P<0.01);而对照组治疗后仅ALT明显低于治疗前,差异有统计学意义(P<0.01),与对照组比较,治疗组TC、TG及ALT下降幅度明显大于对照组,差异有统计学意义(P<0.01)。结论大黄蟅虫胶囊联合卵磷脂治疗高脂血症并NAFLD伴ALT升高患者,在明显降低总胆固醇、甘油三酯、低密度脂蛋白胆固醇的同时能改善肝功能指标。
Objective To investigate the curative effect and safety of Dahuang zhechong capsule combined with leci- thin in the treatment of hyperlipidemia combined with nonalcoholic fatty liver（NAFLD） with elevated alanine aminotransferase（ALT）.Methods 117 patients of hyperlipidemia combined with NAFLD with ALT were randomly divided into treatment group （Dahuang zhechong capsule combined with lecithin） and control group （routine therapy）. Then, total cholesterol（TC）, triglyceride （ TG）, high density lipoprotein （ HDL-C）, low density lipoprotein （LDL-C） and ALT after treatment were compared.Results TC, TG, HDL-C and LDL-C of the treatment group after treatment were significantly lower than those before treatment,so the difference was statistically significant （ P 〈0.01）. While in the control group,only ALT was significantly lower than that before treatment, and the difference was statistically significant（ P〈0.01）.In addition,TC, TG and ALT of the treatment group decreased more significantly than those of the control group, so the difference was statistically significant （ P 〈0.01）.Conclusion Dahuang zhechong capsule combined with lecithin for hyperlipidemia patients with elevated ALT with NAFLD can not only significantly lower TC,TG and LDL-C but also improve index of liver function.
出处
《右江医学》
2014年第3期327-329,共3页
Chinese Youjiang Medical Journal
关键词
大黄蟅虫胶囊
卵磷脂
脂肪肝
高脂血症
谷丙转氨酶
Dahuang zhechong capsule
lecithin
fatty liver
hyperlipidemia
glutamic pyruvic
