摘要
目的观察金黄止咳颗粒的止咳、化痰和抗炎作用。方法分别采用小鼠氨水引咳法、豚鼠枸橼酸引咳法观察金黄止咳颗粒止咳作用,气管酚红排泌法观察其化痰作用,及小鼠二甲苯耳肿胀法和大鼠角叉菜胶性足肿胀法观察其抗炎作用。结果金黄止咳颗粒可明显延长小鼠和豚鼠的咳嗽潜伏期和减少咳嗽次数;显著增加小鼠呼吸道黏膜酚红的排出量,对二甲苯和角叉菜胶所致急性炎症反应有很好的抑制作用。结论金黄止咳颗粒具有明显的止咳、化痰和抗炎作用。
Objective To observe the cough relieving, sputum elimination and anti-inflammation effects of JinhuangZhike Granule （JHZK）. Methods The cough relief effect of JHZK was observed by ammonia water causingcough in mice and citric acid causing cough in guinea pigs. The sputum elimination effect of JHZK was studied bythe observation of tracheal phenol red shedding in mice. The anti-inflammatory effect was tested by xylene swellinginducing on mice and rat＇s toe swelling test caused by carrageen. ResultsJHZK could significantly inhibit the incubationperiod and cough frequency of the model mice and guinea pigs induced by ammonia water and citric acid, and no-tably improve the tracheal phenol red excretion volume in mice, and inhibit acute inflammatory response in mice andrat respectively induced by xylene and carrageen. Conclusion JHZK has certain effects of cough relief, sputumelimination and anti-inflammatory effects.
出处
《中国药物警戒》
2014年第6期325-327,330,共4页
Chinese Journal of Pharmacovigilance
关键词
金黄止咳颗粒
止咳
化痰
抗炎
Jinhuang Zhike Granule
relieving cough
reducing sputum
anti-inflammation
