摘要
目的调查2012—2013年老年病房病原菌临床分布及对抗菌药物的耐药性。方法用回顾性调查,对送检标本同时接种麦康凯平板和血平板,24 h培养出菌落后,进行分离培养、鉴定和药敏试验;用WHONET 5.4软件对药敏结果进行耐药性分析。结果在1485份标本中,共检出病原菌622株,阳性率为41.88%;其中革兰阴性杆菌564株(占90.68%),革兰阳性球菌58株(占9.32%)。铜绿假单胞菌(PA)占革兰阴性杆菌分别为37.75%(94/249),44.76%(141/315);耐甲氧西林金黄色葡萄菌(MRSA)占革兰阳性球菌分别为51.85%(14/27),45.16%(14/31)。PA对美罗培南的耐药率在这2年分别为27.66%,46.81%。结论临床检测的病原菌以革兰阴性杆菌为主,PA检出率呈增高趋势。
Objective To investigate the pathogens distribution and their antimicrobial resistance in geriatric ward in 2012 and 2013, and to provide basis for clinical rational use of antimicrobial drugs. Methods The retrospective survey method was adopted. The submitted samples were inoculated with MaiKangKai tablet and blood agar plate, euhured colonies after 24 h were isolated, identified and susceptibility testing was performed. The software WHONET5.4 was used to analyze the drug susceptibility results. Results Of the1485 samples, 622 pathogens were detected. The positive rate was 41.88%. There were 564 strains of gram negative bacteria, accounting for 90. 68% and 58 strains of gram -positive bacteria, accounting for 9. 32%. Of all gram - negative bacteria, Pseudomonas aeruginosa （PA） accounted for 37.75% （ 94/249 ） and 44. 76% （ 141/315 ） in 2012 and 2013 respectively. Of all gram - positive bacteria, methieillin -resistant Staphylococcus aureus （MRSA） accounted for 51.85% （ 14/27 ）, and 45. 16% （ 14/31 ） in 2012 and 2013 respectively. Pseudomonas aeruginosa＇s resistance rates to meropenem were 27. 66% and 46. 81%, in 2012 and 2013 respectively, increasing by 19. 15%. Resistance rates to aztreonam were 43.62% and 25. 53%, deereasing by 18. 09%. Coneltmion Pathogens detected were mainly gram- negative bacteria. The detection rate of PA tends to increase. To strengthen the pathogen distribution and drug resistance monitoringis of great guiding significance for rational clinical use of antimicrobial agents, and reducing drug resistance rates.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第6期531-533,共3页
The Chinese Journal of Clinical Pharmacology
关键词
病原菌
耐药性
抗菌药物
老年病房
pathogen
drug resistance
antimicrobial agent
geriatric ward
