摘要
目的研究丹参酮ⅡA注射液对独肾肾结石术中减轻肾缺血-再灌注损失的保护作用。方法对该院进行独肾开放性肾切开取石术的27例患者随机分为4组,即不输注丹参酮ⅡA注射液对照组。术前输注丹参酮ⅡA注射液组,术后输注丹参酮ⅡA注射液组,术前联合术后输注处理组,术后检测独肾患者血肌酐(Cr)、尿素氮(Bun)、血清丙二醛(MDA)、血清超氧化物歧化酶(SOD)、血清谷胱甘肽过氧化物酶(GSH-Px)及血清一氧化氮(NO)的变化情况。结果术前用药组和术前术后联合用药组Cr、Bun、MDA较对照组降低,差异有统计学意义(P<0.05);SOD、GSH-Px、NO较对照组升高,差异有统计学意义(P<0.05),术后应用组各项指标与对照组比较,差异无统计学意义(P>0.05)。结论术前积极应用丹参酮ⅡA注射液可有效改善术后肾缺血-再灌注损伤。术后应用对于术中已发生的再灌注损伤无临床疗效。
Objective To study the positive effects of tanshinone Ⅱ A injection in the operation of sole-renal kidney stone surgery in reducing ischemia-reperfusion injury. Methods To pick out 27 patients who are suffered from this kind of disease,which will be separated into four groups at random：without infusion;infusion before operation;infusion after operation;infusion both before and after the operation. And then detecting the chang of elements Cr,Bun,MDA,SOD,GSH-PX,NO of these four groups. Results Contents of elements Cr,Bun,MDA in groups with infusion before operation and groups with infusion before and after the operation are less than the others（P〈0.05）, however, elements SOD,GSH-PX,NO are more than the other two groups（P〈0.05）. There is no statistical significance by compared index in groups of previous infusion and following infusion. Conclusion In order to do some effective contributions to patients＇ recovery, tanshinone Ⅱ A injection should be used to improve the conditions of ischemia-reperfusion injury, nevertheless, it is no useful to patients with infusion after the operation.
出处
《检验医学与临床》
CAS
2014年第11期1515-1516,1518,共3页
Laboratory Medicine and Clinic
关键词
丹参酮
肾结石
独肾
缺血再灌注
tanshinone kidney stones
alone the kidney
ischemia
reperfusion
