摘要
RUNX3是人Runt相关转录因子家族中的一员,它参与细胞的增殖、生长与凋亡的调控。RUNX3表达的异常如杂合缺失、高甲基化与多种恶性肿瘤的发生、发展以及预后有明显的关系,尤其在胃癌、结直肠癌及肝癌的发生、发展中发挥着重要作用。
RUNX3 （hunan Runt-related transcription factor 3 ） plays important roles in regulation on cell proliferation, cell proliferation and cell apoptosis and is a member of the Runt-related transcription factor family. The abnormal expression of RUNX3, such as heterozygous deficiency, hyper-methylation, has significant relationship to the occurrence, development, and prognosis of development of gastric cancer, colorectal malignant tumor, and especially plays important roles in the occurrence and cancer,and liver cancer.
出处
《基础医学与临床》
CSCD
北大核心
2014年第6期866-869,共4页
Basic and Clinical Medicine
基金
河北省卫生厅科研与发展指导计划(072761262)
张家口市科技局2013年度指令性计划(1311055D)
