摘要
目的:探讨奥曲肽诱发血小板减少症的发病机制及临床特点。方法:报告3例因上消化道出血应用奥曲肽后诱发血小板减少症的患者,介绍其临床特征及可能的发病机制。结果:3例患者均在应用奥曲肽数小时后开始出现血小板计数下降,并在停用奥曲肽后逐渐上升。结论:血小板减少症是奥曲肽在治疗消化道出血过程中的少见且严重的并发症,临床医师应对这种潜在的威胁生命的情况提高警惕。
Objective： To explore the pathogenesis and clinical characteristics of octreotide-induced throm- bocytopenia. Methods： The clinical characteristics and process of management of three patients who presented with upper gastrointestinal bleeding complicated of octreotide-induced thrombocytopenia were described in detail. Results ： The three patients presented with thromboeytopenia in several hours after administration of octreotide and regained the platelet count after stopping octreotide. Conclusion： Thrombocytopenia is a rare complication of octreotide therapy and could be life threatening in the setting of upper gastrointestinal bleeding. Physicians should be vigilant in identifying this potentially serious condition.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第11期1344-1346,共3页
Chinese Journal of New Drugs
关键词
奥曲肽
血小板减少症
上消化道出血
octreotide
thrombocytopenia
upper gastrointestinal bleeding
