摘要
目的:观察肛滴平喘汤对慢性阻塞性肺病(Chronic Obstructive Pulmonary Disease,COPD)急性发作模型大鼠脏器指数的影响,为肛滴平喘汤的临床应用提供实验依据。方法:将60只SD大鼠随机分为空白组、模型组、泼尼松组、肛滴平喘汤高剂量组、肛滴平喘汤中剂量组、肛滴平喘汤低剂量组,每组10只,采用熏香烟加气管注射脂多糖法复制COPD急性发作大鼠模型,取每组大鼠肺脏、脾脏、胸腺,分析天平称重,计算脏器指数。结果:与模型组比较,阳性组、肛滴平喘汤高剂量组肺脏指数降低(P<0.05,P<0.05),阳性组、肛滴平喘汤高剂量组、低剂量组大鼠胸腺指数升高(P<0.05,P<0.01,P<0.05),阳性组、肛滴平喘汤高剂量组、中剂量组大鼠脾脏指数升高(P<0.05,P<0.05,P<0.05)。结论:肛滴平喘汤可以有效缓解COPD大鼠模型肺部炎症,减轻慢性阻塞性肺病的急性加重,提高大鼠的免疫力。
Objective To observe the anus drops Pingchuan decoction on chronic obstructive pulmonary disease （COPD） of acuteorgan index model in rats, to provide experimental basis for clinical application of anus drops Pingchuan decoction. Methods： 60 SD ratswere randomly divided into blank group, model group, prednisone group, anus drops Pingchuan decoction high dose group, anus dropsPingchuan decoction middle dose group, anus drops Pingchuan decoction low dose group, 10 rats in each group, using passive cigarettesmoking and intratracheal injection of lipopolysaccharide induced acute episode of COPD rat model, take each rat lung, spleen, thymus,analytical balance, organ index. Results： Compared with the model group, positive group, anus drops Pingchuan decoction high dose groupdecreased lung index （P〈0.05, P〈0.05）, positive group, anus drops Pingchuan decoction high dose group, low dose group of rat thymusindex was increased （P〈0.05, P〈0.01, P〈0.05）, positive group, anus drops Pingchuan decoction high dose group, middle dose rat spleenindex increased （P〈0.05, P〈0.05, P〈0.05）.Conclusion： Anus drops Pingchuan decoction can effectively alleviate the model of pulmonaryinflammation of COPD rats, reduce chronic obstructive pulmonary disease in acute exacerbation, improve the immunity of rats.
出处
《中医临床研究》
2014年第5期13-15,共3页
Clinical Journal Of Chinese Medicine
基金
项目来源:山西省科学技术厅。项目名称:肛滴平喘汤对于慢性阻塞性肺病急性发作的治疗作用及作用机制研究。项目编号:2011031300
关键词
肛滴平喘汤
COPD大鼠
脏器指数
Anus drops Pingchuan decoction
COPD rats
Viscera index
