摘要
目的 体外观察 5 氟脲嘧啶及丝裂霉素合用对人胃癌细胞株 (BGc 82 3)的相互作用。方法 采用MTT法利用中效原理判定两药合用的效果。结果 两种药单独应用时随着药物剂量增加 ,其效应也增加 ;两药大剂量 (大于中效剂量 )合用时协同作用 (CI<1) ,小剂量 (小于中效剂量 )合用时为拮抗作用 (CI>1) ;两药给药时间次序不同不会影响效应大小。结论 上述两种药合用大剂量是协同小剂量拮抗 ,且效应大小与给药时间次序无关。
Objective To observe the anticancer effects of 5 FU and MMC on human gastric carcinoma cell line (BGc 823).Methods The anticancer effect of the drugs was detected with MTT.The median effect principle was used.Results Anticancer effect of the individual drug was enhanced as drug concentration increased. The interaction of the two drugs was cooperate at higher concentration(CI<1) and the sequence of adminisration did not influence the anticancer effects.Conclusion The interaction of the two drugs was cooperated at higher concentration(CI<1) and antagonistic at lower concentration.(CI>1).
出处
《重庆医学》
CAS
CSCD
2001年第2期123-124,共2页
Chongqing medicine
