摘要
目的探讨醒脑静联合乙酰谷氨治疗急性一氧化碳中毒的临床疗效及其对患者血清氧自由基的影响。方法选取ACOP患者90例,随机分为观察组与对照组。2组患者入院后均给予维持血压、降低颅压等常规治疗,并于入院1~2 h内配合高压氧舱治疗。观察组在上述治疗的基础上给予醒脑静联合乙酰谷氨治疗,对照组给予乙酰谷氨治疗,对比2组患者显效时间、临床疗效及治疗后3 d、1周、2周后血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）活性及丙二醛（MDA）水平变化情况。结果观察组治疗后各时间点血清SOD、GXH-PX活性、MDA水平改善均较对照组显著增高,组间比较差异有统计学意义（P〈0.05）。且观察组显效时间明显短于对照组。治疗总有效率显著高于对照组（93.3%和77.7%）,组间比较差异有统计学意义（P〈0.05）。结论醒脑静联合乙酰谷氨可有效清除ACOP患者体内氧自由基,减少其对脑细胞的损害,可作为治疗急性一氧化碳中毒的有效治疗方案。
Objective To investigate the clinical curative effect of Xingmwjing combined with acetyl glutamine on acute carbon monoxide poisoning （ACOP）, and its effect on the serum oxygen free radicals of patients. Methods A total of 90 patients with ACOP admitted in hospital were randomly divided into observation group and control group. Patients in both groups were performed conventional treatment to maintain blood pressure and lower cranial pressure after admission, and with hyperbaric treatment in the hospital within 1 to 2 hours. On the basis of the above treatment, the observation group adopted Xingnctojing combined with acetyl glutamine, while the control group adopted acetyl glutamine, with a comparison of the re- eovery time, clinical effect, and the changes of serum superoxide dismutase （SOD）, glutathione peroxidase （GXH-PX） activ- ity and malondialdehyde （MDA） after 3 days, 1 week and two weeks of the treatment respectively. Results The serum SOD, GXH-PX activity and MDA of the observation group improved significantly higher than that of the control group at each time point after treatment. There is statistical significance in the comparative differences between groups when P is lower than 0.05. Besides, the recovery time of the observation group was obviously shorter than that of the control group, and the total effective rate of the former （93.3 % ） was much higher than that of the latter （77.8 % ）. Again, there is statistical signifi- cance in the comparative differences between groups when P is lower than 0.05. Conclusion The combination of Xingnao- ring with acetyl glutamine can efficiently remove the oxygen free radicals in the body of the patients with ACOP, reduce the damage to the brain cells, and is an effective therapy for acute carbon monoxide poisoning.
出处
《吉林中医药》
2014年第5期447-449,共3页
Jilin Journal of Chinese Medicine
基金
河北省科技支撑项目(131200953)
关键词
醒脑静
乙酰谷氨
一氧化碳中毒
氧自由基
Xingnaojing
Acetyl glutamine
Carbon monoxide poisoning
Oxygen free radicals
