摘要
对2-氯-x-甲基吡啶合成2-氯-x-三氟甲基吡啶的一些反应规律进行了研究、分析和总结,认为吡啶环上N原子的占位和α位上是否存在吸电子基团决定侧链氯化的可行性,在合成反应中,氯化反应难易程度与氟化反应的难易程度存在着负相关。
Synthesis reaction principles of 2-chloro-3-（trifluoromethyl）pyridine were analyzed and summarized. It’s pointed out that ,N occupying on the pyridine ring and whether there is electron withdrawing group onαsite determine the feasibility of side-chain chlorination;in synthesis reaction, the difficulty of chlorinating is negatively correlated with the difficulty of fluorinating.
出处
《当代化工》
CAS
2014年第5期709-711,共3页
Contemporary Chemical Industry
