摘要
以对氯苯胺为起始原料,经重氮化、氯取代化、环合、酯化、酰胺化5步反应,合成了目标化合物N-(2-氨乙基)-1-对氯苯基-5-甲基-1,2,3-三唑-4-甲酰胺,考察了影响三唑酯与乙二胺酰胺化反应的条件,优化反应条件为:n(三唑酯)∶n(乙二胺)=1∶25,在乙醇中回流反应8 h,优化条件下,目标化合物的收率达88%,其结构经1H NMR和MS确证。
N-（2-Aminoethyl）-1-（4-chlorophenyl）-5-methyl-1,2,3-triazole-4-carboxamide was synthesized through five steps using 4-chlorobenzenamine as the starting material. The reaction conditions between triazole ester and ethylene diamine were explored and determined as follows： reaction temperature around 78℃, reaction time 8 h, n（triazole ester）： n（ethylenediamine）=1：25. The yield of the topic compound was up to 88% and the product was characterized by ^1H NMR and MS.
出处
《精细化工中间体》
CAS
2015年第4期28-30,共3页
Fine Chemical Intermediates
基金
兰州石化职业技术学院科技项目
关键词
杂环化合物
甲酰胺
三唑
heterocyclic compounds
carboxamide
triazole
