冠心病患者血管性血友病因子检测的临床价值被引量：2

Clinical value of detection of plasma vWF in patients with coronary artery disease

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摘要冠心病（coronary artery disease,CAD）是当今危害人类健康的严重心血管疾病,其发病率在我国呈逐年上升趋势。研究表明,动脉粥样硬化（AS）并不单纯是由胆固醇和脂质在血管壁内沉积后发生慢性炎症而造成的,而是一个多病因、复杂的病理生理过程[1]。脂质代谢异常是CAD发病的重要因素之一, In this study we explored the clinical value of detection of plasma von Willebrand factor（vWF）in patients with coronary artery disease（CAD）.We enrolled 104in-hospital patients with CAD and 96control subjects with health examination in clinic service.Their plasma vWF level and serum TC,TG,HDL-C and LDL-C were measured.The vWF,LDL-C and TC level in CAD group were statistically much higher than those in control group（P〈0.05）.The morbidity of CAD in group of lipids normal with vWF150% was higher than that in control group.It indicated that elevated vWF level may be an independent risk factor for occurrence of CAD which blood lipids was not increased.

作者袁忠海侯毅鞠赵臣张丽张慧李中言

机构地区吉林医药学院检验学院血液学检验教研室吉林医药学院附属医院检验科吉林医药学院附属医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2014年第5期450-452,共3页 Journal of Clinical Cardiology

基金吉林省教育厅"十一五"科学技术研究基金资助(No:2009-510)

关键词冠心病血管性血友病因子临床价值 coronary artery disease von Willebrand factor clinical value

分类号 R541.4 [医药卫生—心血管疾病]

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1袁忠海,侯毅鞠,李艳,张慧,李中言,李欣,于东汇.冠心病患者vWF基因A1381T多态性分析[J].中国实验血液学杂志,2011,19(3):775-780. 被引量：7

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