摘要
目的探讨肺血栓栓塞症(PTE)患者炎性标志物及纤溶标记物活性改变的临床意义。方法选择2008年3月-2012年10月新疆医科大学第一附属医院收治的386例PTE患者(PTE组)及250例健康对照人群(对照组),采用酶联免疫吸附试验(ELISA)方法检测血浆超敏C-反应蛋白(Hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、血浆组织型纤溶酶原激活剂(t-PA)、血浆组织型纤溶酶原抑制剂(PAI-1)、D-二聚体(DD)及纤维蛋白原(FIB)水平。结果 PTE组血浆炎性因子Hs-CRP、IL-6、TNF-a水平较对照组明显升高(P<0.05)。PTE组血浆纤溶标志物PAI-1、FIB、DD、t-PA水平较对照组明显升高(P<0.05)。纠正了年龄、性别、高脂血症、吸烟、糖尿病等危险因素及血浆IL-6、TNF-a、FIB、t-PA水平后,多元Logistic回归分析提示Hs-CRP、PAI-1、DD水平及肥胖为PTE患者的独立危险因素。结论 PTE患者处于纤溶功能减退及炎症状态,测定炎性因子及纤溶指标有助于早期诊断、减少漏诊及指导临床早期干预治疗。获得性危险因素中肥胖为PTE患者的独立危险因素,因此在PTE的防治方面对这类人群的生活习惯早期干预特别重要。
Objective To study the inflammatory markers and fibrinolytic activity and explore their clinical significance in patients with pulmonary thromboembolic disease （PTE） .Methods Measure the levels of High-sensitive C-reactive protein （Hs-CRP） ,white referral prime-6 （IL-6） ,tumor necrosis factor （of TNF-a） ,plasma tissue-type fiber plasminogen activator （t-PA） ,plasma tissue-type plasminogen inhibitor （PAI-1） ,D-dimer （DD） and fibrinogen （FIB） level by ELISA to make a comparison between 386 PTE pa-tients （PTE group from March ,2008 to October ,2012） and 250 healthy population（control group） .Re-sults The levels of inflammatory factors such as Hs-CRP ,IL-6 ,TNF-a are significantly higher in PTE group than controls （P 〈0.05） .After adjusting for age ,gender ,hyperlipidimia ,smoking ,diabetes ,and levels of IL-6 ,TNF-a ,FIB and t-PA ,logistic regression analysis indicated that Hs-CRP ,PAI-1 ,DD and obesity are independent risk factors for both for PTE patients .Conclusion PTE patients are in the fibrino-lytic dysfunction and inflammation condition ,and measuring the levels of inflammatory cytokines and fi-brinolysis will contribute to early diagnosis ,reduction of misdiagnosis and guidance to the clinical early in-tervention .In addition ,obesity is an independent risk factors for the patients with PTE .
出处
《新疆医科大学学报》
CAS
2014年第6期708-711,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2011211A062)
关键词
肺血栓栓塞症
炎性标志物
纤溶
pulmonary thromboembolism
inflamatory markers
fibrinolytic markers
